An ‘exciting’ pill can make human blood poisonous to mosquitoes and kill them, research suggests. Scientists discovered the disease-carrying flies died after feeding on the blood of humans given super-strength doses of ivermectin.
Ivermectin is an antiparasitic drug and in lower doses is widely used in the treatment of other tropical diseases. It has safely been used in doses up to 10 times the standard dose.
The mosquito-killing effects lasted up to a month after patients were given the drug, which is already used to treat scabies.
Researchers now hope the drug could be used to stem the control of malaria, and potentially other mosquito-borne diseases.
A team of British-led researchers split 139 volunteers from Kenya, which reports more than six million new cases of malaria each year, into three groups.
The malaria patients were randomly chosen to be given 600mcg/kg or 300mg/kg of ivermectin for three days or were given a placebo.
The study, published in The Lancet Infectious Diseases, revealed that both doses of ivermectin were poisonous to mosquitoes for up to 28 days. It also showed 97% of the mosquitoes died two weeks after feeding on the blood of patients given the higher dose of ivermectin.
The scientists, which included a team from the Kenya Medical Research Institute and the US Centers for Disease Control and Prevention, fed the mosquitoes in cages using blood samples taken from the volunteers.
Dr Menno Smit, lead researcher, from the Liverpool School of Tropical Medicine, welcomed the findings, TechTimes reports.
He said, “The most exciting result was the fact even one month after the subjects took ivermectin, their blood was still killing mosquitoes.”
However, the researchers believe the 300mcg/kg dose offers the best hope due to the adverse effects from the higher dose.
An analysis revealed 11% of the 45 volunteers given the 600mcg/kg dose experienced adverse effects to the drug. The standard dose is 150mcg/kg.
Only 4% of the 48 patients who received the smaller dose had similar complaints. No side effects were reported from the placebo.
Researchers wrote in the journal: ‘Ivermectin at both doses assessed was well tolerated and reduced mosquito survival for at least 28 days after treatment.’
‘Ivermectin 300mcg/kg per day for three days provided a good balance between efficacy and tolerability.’
They added it ‘shows promise as a potential new tool for malaria elimination.’ It was given alongside the anti-malarial drug dihydroartemisinin-piperaquine.
Ivermectin, branded a ‘wonder drug’ by some researchers, was developed to kill parasites responsible for river blindness and elephantiasis.
Preliminary results of the new study were presented at a World Health Organization (WHO) evidence review group meeting.
It works as a completely new type of anti-malarial drug that kills mosquitoes, as opposed to existing drugs that target the parasite.
Disease-carrying mosquitos kill more than 750,000 people a year, many of whom being children, global figures show.
Climate change warming the planet is allowing for mosquitos to spread from their usual habitats, posing a risk to many in the northern hemisphere.
Source: Daily Mail