India: Researchers discover a molecule to stop degeneration

Now Indian researchers have made headway towards finding a molecule that can stop degeneration as well as promote regeneration of articular cartilage. The results of the study have been published in the journal, Development. Experts give their opinion to My Medical Mantra regarding the same

India: Researchers discover a molecule to stop degeneration

  • Osteoarthritis is a joint inflammation that results from cartilage degeneration. Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease. Deterioration of articular cartilage in joints causes osteoarthritis.
  • Researchers are engaged in developing new strategies for osteoarthritis treatment based on regenerative medicine, tissue engineering and gene therapy.


As per Amitabha Bandyopadhyay, who led the research team explained, We worked on mice and chicken embryos, that both permanent and transient cartilage (which later turns into the bone) are formed from the same cell, influenced by different genes. We demonstrated in mice and chick embryos that permanent cartilage can be turned into transient cartilage under the influence of the same gene that is responsible for the formation of bones in an embryo.

Speaking about the same, Dr Sudhakar Lawand, Consultant Orthopaedic Surgeon, Omkar, Lawand Orthopaedic Clinic, Satara said, “Degeneration is a natural process. It is aging of the joints, tissues and cells. And one cannot stop it.”

Dr Nadir Shah, Associate Professor in Orthopaedics of JJ Hospital said, “Degeneration cannot be stopped.  It is not possible. It cannot be reversed nor stopped. Exercise, healthy diet, marinating a healthy weight and muscle strengthening.