Fibre intake is crucial so that you aren’t eaten by your own microbes

Studying the interaction of fibre, gut microbes and the intestinal barrier system is that if you don't feed them, they can eat you, say researchers

gut-bacteria-2The gut micro biota plays a crucial role in maintaining our body’s overall health. New research shows what happens if we do not feed our gut microbes with the fibre they need to survive.

Our gut micro biota contains at least 1,000 different species of known bacteria, summing up 3 million genes.

We share one third of our gut bacteria with other people, while the composition in our other two thirds is unique to each one of us.

Gut micro biota is important to our health because it contributes to a healthy immune system by acting as a barrier against other harmful microorganisms

It also helps with digesting foods that the stomach and small intestine have not been able to digest, as well as producing some vitamins.

We have always been told by healthcare professionals and nutritionists that fibre is important to a healthy diet.

But new research examines exactly what happens if our intestinal microbes do not receive the appropriate amount of fibre.

Studying the behaviour of gut bacteria in mice

The study was carried out by an international team of researchers led by Eric Martens, Ph.D., associate professor of microbiology at the University of Michigan Medical School, and Mahesh Desai, Ph.D., from the Luxembourg Institute of Health.

Researchers bred mice especially for the study. Mice were born and raised without any gut bacteria of their own. They then received a transplant of 14 bacteria that normally live in the human gut.

Knowing the genetic signature of each bacterium, scientists were able to track the evolution of each one of them over time. They used a germ-free lab facility and genetic techniques that allowed them to see what bacteria were present and active under different dietary conditions.

Researchers infected the mice with a strain of bacteria that is the equivalent of E. coli in humans. Then they examined the impact of diets with varying amounts of fibre, as well as a diet with no fibre at all.

Researchers tried a diet that was 15 per cent fibre, made from minimally-processed grains and plants. They also tried a diet that was rich in prebiotic fibre – a purified form of soluble fibre that is similar to what some processed foods and dietary supplements contain.

Gut microbes really need their fibre

As revealed by the study – published in the journal Cell – the induced infection did not fully spread in mice that received the 15 percent-fiber diet. Their mucus layer remained thick, protecting them against the infection.

But when scientists replaced the diet with one that lacked fibres altogether, gut microbes started eating the mucus. Even a few days of fibre deprivation led the bacteria to start invading the colon wall.

Gut microbes rely on fibre for their food, and when they do not get it, they start eating away at your gut. This makes the gut more prone to infections.

The diet rich in supplement-like prebiotic fibre had the same results as the diet lacking fibre completely. The mucus layer started eroding as a result of the action of microbes.

“The lesson we’re learning from studying the interaction of fibre, gut microbes and the intestinal barrier system is that if you don’t feed them, they can eat you.”

Researchers were also able to see what fibre-digesting enzymes the bacteria were making. They found 1,600 different enzymes that digest carbohydrates – a complexity similar to the one found in the human gut.

A lack of fibre also triggered a higher production of such mucus-degrading enzymes.

Scientists were able to look at images of the “goblet” cells on the colon wall that produce mucus. They could clearly see how the mucus layer got progressively thinner as the mice received less fibre.

In a normal gut, mucus is being produced and degraded at a steady pace. But on a fibre-deprived diet, mucus was degraded at a much higher pace than it was produced.

Examining the gut tissue of infected mice, researchers were able to see inflammation across a wide area of thinning, and even patchy tissue.

Infected mice that received a diet rich in fibre also displayed inflammation but across a much smaller area.

Future research to study different diets

In the future, Martens and Desai hope to study the effect of different prebiotic combinations over a longer period of time, as well as the impact of an intermittent natural fibre diet.

Researchers would also like to find the biomarkers that signal the state of the mucus layer in human guts, such as the number of mucus-degrading bacteria.

Martens and Desai also wish to study the impact of a low-fibre diet on chronic illnesses such as inflammatory bowel disease.

“While this work was in mice, the take-home message for humans amplifies everything that doctors and nutritionists have been telling us for decades: Eat a lot of fibre from diverse natural sources.

Your diet directly influences your micro biota, and from there it may influence the status of your gut’s mucus layer and tendency toward disease. But it’s an open question of whether we can cure our cultural lack of fibre with something more purified and easy to ingest than a lot of broccoli.”

Source: Medical News Today