Early use of breast milk could play a ‘vital role’ in preventing heart disease in prematurely born infants, according to research by the Royal College of Surgeons in Ireland (RCSI) and the Rotunda Hospital.
One of the long-term health complications that young adults who were born prematurely may have is unique heart characteristics. These can include smaller heart chambers, relatively higher blood pressure, and a disproportionate increase in muscle mass in the heart.
The new research, published in the journal Pediatric Research, was written in collaboration with researchers from Harvard Medical School, University of Oxford and University of Toronto.
One study cited in the article looked at 30 preterm-born adults who were assigned to receive exclusive human milk and 16 preterm-born adults who were assigned to receive an exclusive formula-based diet during their hospital stay at birth.
They then underwent a detailed cardiovascular assessment between 23 and 28 years of age, including an MRI of their hearts.
As expected, all of the hearts of those born prematurely had smaller chambers than the hearts in people who were not born prematurely.
However, the study showed that the smaller heart chambers were less profound for the exclusively human milk-fed group in comparison to those who were exclusively formula-fed, suggesting a potentially protective effect of human milk for heart structure.
The researchers then identified potential reasons for why breast milk results in a lower risk of heart disease.
Afif EL-Khuffash, honorary clinical professor of paediatrics at RCSI and consultant neonatologist at the Rotunda Hospital, Dublin, said the research could play a role in better treatment options.
“It is becoming increasingly clear that premature birth results in long-term adverse cardiovascular effects with important clinical consequences,” he said.
“There is a distinct lack of preventative and therapeutic interventions available to alleviate those effects.
“The current evidence comes from observational studies and highlights the strong link between early breast milk administrations and improvement in long-term heart health, but it lacks concrete mechanistic explanations.
“More studies on the composition of breast milk could make clear exactly what causes these health benefits, which could, in turn, lead to better treatment options.”
Breast milk, they said, could help prevent heart disease by better-regulating hormones and growth factors, strengthening the infant’s immune system, reducing inflammation and by possibly improving the metabolism of the child.
The research concluded that identifying the key components within breast milk that results in improved heart health could pave the way for a more targeted approach to improve long-term cardiovascular wellbeing for those born prematurely.
While speaking to My Medical Mantra, Dr Lalit Lavankar, a paediatric cardiologist from Nashik, “Human breast milk has been proven to reduce the risk of coronary artery disease and arteriosclerosis in premature babies. Breast milk is the best nourishment for babies. It is beneficial for the child’s growth and has a positive effect on the infant’s heart. Compared to children who are born full-term, preterm babies are at a higher of heart disease.”
Source: Irish Times